IJCNMH ARCpublishing

Issue: Issue 1 (2014)


Parkinson's disease cluster: the wind of change

Ana Monteiro and João Massano
This paper aims at demonstrating that “Parkinson’s disease” (PD) is an umbrella designation for a number of heterogeneous disorders sharing an important number of clinical features, but separated by significant differences. In fact, PD should probably be regarded as a “Parkinson’s disease cluster”, and the core clinical features termed Parkinson syndrome. Disease manifestations, genetic underpinnings, and pathological findings argue against a unique disease process and, hence, a unique management approach, especially one that aims solely at the improvement of later (i.e. motor) disease manifestations. We propose that true therapeutic innovation in PD calls for a leap in concepts and shift in research efforts. Disease-specific neuroprotective agents targeting early molecular and pathological events should ideally be developed.

Keywords: Parkinson's disease, Parkinson's disease cluster, Genetics, Pathophysiology, Neuropathology, Therapeutics, Clinical trials, Neuroprotection.

International Journal of Clinical Neurosciences and Mental Health 2014; 1:7

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