IJCNMH ARCpublishing

Issue: Issue 4 (2017) – Supplement 3

Review Article

A relationship between early life stress and depression: the role of the serotonin transporter gene polymorphism (5-HTTLPR)

Jorge Valderrama, Carlos N. Pato, and Michele T. Pato
Early life stress has been associated with many different negative outcomes including adulthood depression. Studies have suggested a role of the serotonin transporter gene polymorphism (5-HTTLPR) in explaining this relationship. However, consistent replication of this gene-environment interaction have proven difficult. This paper will review contrasting evidence assessing this interaction. Previous research has revealed a complex interplay of factors that might explain how certain 5-HTTLPR genotypes interact with early life stress to produce sensitivity to stress and adulthood depression. Maladaptive cognitive and behavioral patterns will be reviewed in light of 5-HTTLPR’s impact on brain regions associated with mood regulation. Future research directions and clinical interventions will also be discussed.

Keywords: Early life stress, Childhood abuse, 5-HTTLPR, Depression.

Special Issue on the Neurobiology of Mental Illness

International Journal of Clinical Neurosciences and Mental Health 2017; 4(Suppl. 3):S09
DOI: https://doi.org/10.21035/ijcnmh.2017.4(Suppl.3).S09
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