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Issue: Issue 4 (2017) – Supplement 3


Review Article

Circulating biomarkers in schizophrenia: a proteomics perspective

Author(s):
Cátia Santa, Joana F. Coelho, Nuno Madeira and Bruno Manadas
Abstract:
Schizophrenia (SCZ) is one of the most severe and devastating major mental disorders, with an onset typically in late adolescence or early adulthood affecting about 0.5–1.2% of the population worldwide. It is one of the most debilitating medical conditions, with striking socio-economic burden to society due to lost employment and social support that largely surpass direct costs of treatment. SCZ is listed by the World Health Organization (WHO) among the top 20 leading causes of disability worldwide. Its diagnosis is syndromic, based in clinical interviewing and anamnesis, as there is to date no biochemical test to aid in this diagnosis. On the other hand, SCZ treatment is mostly based in antipsychotic drugs which are in several aspects somehow ineffective, and some of these medications have low tolerability with severe side effects. For all these reasons, the current search for new panels of biomarkers is of the utmost importance to aid in the correct diagnosis and stratification of the patients, prognosis, and prediction of treatment effectiveness. In this review, a total of 25 publications on peripheral SCZ biomarkers are presented from proteomics studies performed in body fluids of patients searching for protein markers, and using mass spectrometry. To date such proteomics studies have already been achieved in cerebrospinal fluid (CSF), serum, plasma, peripheral blood cells (namely, mononuclear cells, T-cells and red blood cells), saliva, and sweat, being of paramount importance in the schizophrenia research field, but still lacking validation and clinical translation. In summary, a general overview of the results from these 25 studies, as well as the challenges and future perspectives of the field, are presented and discussed.

Keywords: Schizophrenia, Biomarkers, Proteomics, Mass Spectrometry.

Special Issue on the Neurobiology of Mental Illness

International Journal of Clinical Neurosciences and Mental Health 2017; 4(Suppl. 3):S05
DOI: https://doi.org/10.21035/ijcnmh.2017.4(Suppl.3).S05
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