IJCNMH ARCpublishing

Issue: Issue 4 (2017)

Review Article

Biomarkers and schizophrenia: a qualitative review

Joana Ribeiro da Silva and Sara Azevedo Pinto
Schizophrenia (SCZ) is a psychiatric disorder with a broad spectrum of biological and clinical manifestations of yet not completely clear pathophysiological mechanisms. Several lines of evidence have been supporting the idea that immunoinflammatory, oxidative, hormonal and cellular dysfunctions are implicated on the biomolecular basis of SCZ. However, accurate diagnosis and selection of appropriate treatments remains challenging as a result of the scarcity of objective tests. Furthermore, there is a compelling need to find biomarkers that could predict drug response and tailor pharmacological treatment, particularly in drug-naïve first episode psychosis (FEP). Hence, numerous technologies have been employed in order to search for SCZ biological markers, but evidence relating them to treatment efficacy is lacking. In this regard, some preliminary data suggest promising results. The current review provides information on: (1) potential biomarkers associated with biological disturbances and (2) biological markers associated with treatment response.

Keywords: Schizophrenia, Biomarkers, Treatment.

International Journal of Clinical Neurosciences and Mental Health 2017; 4:2
DOI: https://doi.org/10.21035/ijcnmh.2017.4.2
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