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Issue: Issue 3 (2016) – Supplement 1


Lecture

Molecular aging: a primary or secondary trigger in late onset myopathies?

Author(s):
Vered Raz
Abstract:
The genetic cause for OPMD is an alanine expansion in PABPN1. PABPN1 encodes for RNA binding protein, involved in multiple steps of RNA processing. The protein is ubiquitously expressed but symptoms in OPMD start only from midlife onwards, and initially are limited to only few muscles. This enigma is not fully understood. Recent data correlating molecular and pathological changes with symptoms reveals the most prominent affected molecular pathway in OPMD and key regulators that cause muscle weakness in OPMD. A better understanding of OPMD pathology could lead to better therapeutic developments.

Special Issue on Controversies in Neurology. From the 10th World Congress on Controversies in Neurology (CONy), Lisbon, Portugal. 17–20 March 2016.

International Journal of Clinical Neurosciences and Mental Health 2016; 3(Suppl. 1):L42
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